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| Nanomechanics of biomolecules: focus on DNA Y. Eugene Pak
The Journal of Mechanical Science and Technology, vol. 23, no. 7, pp.1949-1958, 2009
Abstract : Nano-mechanical measurements and manipulations at the single-cell and single-molecular levels using the atomic
force microscope (AFM) and optical tweezers are presenting fascinating opportunities to the researchers in bioscience
and biotechnology. Single molecule biophysics technologies, due to their capability to detect transient states of molecules
and biomolecular complexes, are the methods of choice for studies in DNA structure and dynamics, DNA-DNA
and DNA-protein interactions, and viral DNA packaging. The aim of this review is to describe the recent developments
of scientific tools and the knowledge gained in single molecule DNA mechanics such as DNA elasticity, electrostatics,
condensation and interactions of DNA with surrounding fluids during its hydrodynamic flow.
Keyword :
Nanomechanics; DNA; Optical tweezers; Atomic force microscopy
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